Therapeutic Spice

Pain Relief & CB2

Caryophyllene/humulene-dominant. The only terpene that binds CB2 receptors, providing targeted pain relief and anti-inflammatory action.

6+ Strains
19.1% THC avg
0.5% CBD avg
Anytime
Uncommon (~15%)
Dominant Terpenes: Caryophyllene Humulene Myrcene

Terpene Profile

Centroid values (mg/g) from the 2025 German study

Caryophyllene Dominant
3.63 mg/g

Spicy, Peppery

Myrcene Dominant
1.98 mg/g

Earthy, Herbal

Limonene
1.46 mg/g

Citrus, Lemon

Humulene Dominant
1.45 mg/g

Woody, Hoppy

Pinene
1.08 mg/g

Pine, Forest

Linalool
0.93 mg/g

Floral, Lavender

Fenchol
0.30 mg/g

Camphor, Pine

Terpinolene
0.19 mg/g

Herbal, Fruity

Ocimene
0.14 mg/g

Sweet, Citrus

Total Terpenes 11.16 mg/g

Primary Effects

Pain relief CB2 activation Anti-inflammatory Appetite modulation

Best For

  • Chronic pain management
  • Inflammatory conditions
  • Arthritis and joint discomfort
  • Those seeking medical benefits
  • Anytime therapeutic use

Therapeutic Potential

Pain relief via CB2 Anti-inflammatory Appetite suppression Gastric protection Anxiety reduction

Benefits

  • Targeted pain relief through CB2 activation
  • Anti-inflammatory action
  • Appetite modulation from humulene
  • Spicy, complex flavor profile
  • Therapeutic without heavy sedation

Consider Alternatives If

  • You want purely recreational effects
  • You dislike spicy/peppery flavors
  • You're seeking strong euphoria

Therapeutic Spice Strains

6 strains matching pain relief & cb2 profiles

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9D4 cannabis strain
☯️Hybrid

9D4

9D4 is a potent 70% Indica/30% Sativa hybrid crossing 1994 Super Skunk with Original Glue. With 19-25% THC and signature skunk aromatics, this classic breed delivers an immediate creative head high layered with full-body relaxation—ideal for artistic work and experienced consumers seeking authentic, hard-hitting effects.

🌈Entourage High
RelaxedCreativeHappy

70% Indica / 30% Sativa

Air Hug cannabis strain
☯️Hybrid

Air Hug

Air Hug is a perfectly balanced 50/50 hybrid from Growers Choice Genetics that lives up to its comforting name. Crossing GMO with Secret Mints, this strain delivers sweet, minty, and earthy flavors with a spicy Caryophyllene kick. Testing between 18-25% THC, it offers accessible euphoria, enhanced creativity, and clear-headed focus paired with gentle physical relaxation. Ideal for afternoon or evening use when you want to stay productive yet calm—like a warm embrace for your mind and body.

🌶️Relief High
euphoriacreativityfocus

50% Sativa / 50% Indica

A1 cannabis strain
☯️Hybrid

A1

A1 is a classic indica-leaning hybrid with Afghani heritage, delivering dense, resinous buds and earthy, hash-forward aromatics. Expect profoundly relaxing, body-heavy effects perfect for evening use, pain relief, and sleep support—a reliable choice for those seeking deep calm without overwhelming sedation.

🌈Entourage High
RelaxingEuphoricHappy

55% Indica / 45% Sativa

Agape cannabis strain
☯️Hybrid

Agape

Agape is a beautifully balanced hybrid that wraps you in unconditional relaxation. With Myrcene-dominant terpenes delivering sweet berry and earthy pine flavors, this strain offers an ideal blend of euphoric mental clarity and soothing physical calm. Perfect for creative sessions, stress relief, or winding down, Agape provides therapeutic benefits without overwhelming intensity—making it a versatile choice for afternoon and evening consumption.

🌈Entourage High
euphoriarelaxationcreativity

60% Sativa / 40% Indica

Agharta cannabis strain
☯️Hybrid

Agharta

Agharta is a versatile hybrid strain blending Northern Lights and Afghani genetics, delivering 15-20% THC alongside a myrcene-dominant terpene profile. This cultivar offers an elegant balance of uplifting euphoria and creative stimulation that gradually transitions into deep, satisfying relaxation. Its complex flavor weaves together earthy sweetness, pine, and subtle spice. Ideal for afternoon or evening sessions, Agharta appeals to those seeking stress relief, creative inspiration, and restful preparation without immediate sedation—a sophisticated choice for both recreational enjoyment and therapeutic support.

🌈Entourage High
EuphoriaRelaxationCreativity

60% Sativa / 40% Indica

1:1 Punchinella cannabis strain
☯️Hybrid

1:1 Punchinella

1:1 Punchinella is a balanced hybrid offering equal parts THC and CBD, delivering gentle euphoria, relaxation, and mood enhancement without overwhelming effects. Perfect for pain relief, creativity, and anxiety reduction—ideal for both beginners and experienced users seeking therapeutic benefits alongside mild psychoactive effects.

🍋Uplift High
RelaxationPain ReliefEuphoria

50% Sativa / 50% Indica

Frequently Asked Questions

Common questions about Therapeutic Spice strains

Why is caryophyllene special for pain relief?

Caryophyllene is the only terpene known to directly bind to CB2 cannabinoid receptors. This means it can provide anti-inflammatory and analgesic effects without the psychoactive intensity of THC binding to CB1 receptors. The 2025 study found this cluster has the highest caryophyllene concentration (3.63 mg/g).

How does humulene affect appetite?

Unlike THC which typically increases appetite, humulene may have appetite-suppressing properties. This cluster has the highest humulene concentration (1.45 mg/g), which may help moderate the munchies effect while providing anti-inflammatory benefits. Humulene is also found in hops and ginger.

Is this cluster good for functional daytime use?

Yes! The Therapeutic Spice cluster is recommended for 'anytime' use because it focuses on body effects rather than heavy mental sedation. The balanced terpene profile provides relief without significant impairment, making it suitable for medical users who need to maintain functionality.

Explore Other Clusters

Discover different terpene profiles for various effects

😌

Relaxing Body

Sedating Body High

🍋

Uplifting Citrus

Mood Elevation

⚡

Rare Energizer

Energizing Focus

☯️

Gentle Balance

Beginner Friendly

🌈

Full Spectrum

Entourage Effect

🌶️

Ready to Explore More?

Use our strain finder to discover Therapeutic Spice strains or explore other chemovar clusters.

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