Hemp readily absorbs toxic elements—urgent need for safety testing standards

The Determination of potentially toxic elements (Arsenic, Cadmium, Mercury, and Lead) in Hemp (Cannabis sativa L.) from using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP OES).

Journal of AOAC International • • Moderately Relevant
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AI Summary

Hemp plants are natural "bioaccumulators" that readily absorb potentially toxic elements (PTEs) like arsenic, cadmium, mercury, and lead from the soil they grow in. This research tested a laboratory method called Inductively Coupled Plasma Optical Emission Spectroscopy (ICP OES) to measure these harmful contaminants in hemp products. The study is particularly important because non-intoxicating hemp products sold in New Jersey—and potentially elsewhere—currently lack mandatory testing for these toxins, creating a significant consumer safety gap. Exposure to these elements is linked to serious health consequences including cancer, kidney damage, and neurological harm.

The research team validated the ICP OES method by processing hemp samples and measuring their toxic element content. The results were mixed: the method successfully detected and measured cadmium and lead with acceptable accuracy (92.7% and 96.2% recovery rates), meeting industry standards. However, the method fell short for mercury and arsenic, failing to detect these elements at the trace levels required for consumer protection. Mercury recovery was particularly poor at only 47%, while arsenic concentrations were too low for reliable detection.

The practical takeaway is clear: while ICP OES offers a cost-effective screening tool for cadmium and lead in hemp products, it's insufficient for comprehensive safety testing. The researchers recommend switching to a more sensitive technique called ICP MS (Inductively Coupled Plasma Mass Spectrometry) for detecting arsenic and mercury. This finding highlights an urgent need for mandatory PTE testing standards in hemp products to protect consumers from accumulated toxic elements that pose real health risks through regular use.

📄 Original Abstract

Hemp (Cannabis sativa L.) readily accumulates potentially toxic elements (PTEs) from soil. PTE exposure is linked to cancer, nephrotoxicity, and neurotoxicity. Non-intoxicating hemp products in New Jersey are not subject to mandatory PTE testing, posing a consumer safety risk. This study presents a single-laboratory validation of an ICP OES method for the determination of As, Cd, Pb, and Hg in hemp, evaluated against AOAC SMPR 2020.001 performance criteria. Ground hemp (0.125 g) was digested using HNO3/HCl/H2O2 (190 °C, 20 min) and diluted to 50 mL. Samples were analyzed on an Agilent 5800 ICP OES with a seven-point calibration (1-100 μg/L), Au/Sc internal standards, and KHP carbon for matrix matching. Spike recoveries for Cd (92.7%) and Pb (96.2%) met AOAC SMPR 2020.001 criteria (80-115%). Mercury recovery (47%) fell below acceptance limits due to matrix suppression and volatility losses. The As LOD (0.807 μg/g) exceeded sample concentrations in most specimens. LOQ values for all four elements exceeded the SMPR 2020.001 threshold of 10 µg/kg (0.01 µg/g). Calibration linearity was confirmed for all analytes (r ≥ 0.995). Partial validation was achieved: Cd and Pb demonstrated acceptable accuracy and repeatability, but LOQ criteria were not met for any analyte. ICP OES is not suitable for Hg or As at regulatory trace levels; ICP MS is recommended for these elements. This method offers a cost-effective screening tool for Cd and Pb in hemp. This study presents the first single-laboratory ICP OES validation for PTEs in hemp under AOAC SMPR 2020.001. Cd and Pb met accuracy and repeatability criteria; As and Hg did not meet sensitivity requirements. ICP MS is recommended for regulatory As and Hg testing in hemp.

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