How crystal engineering could help keep cannabinoids stable
Structure-stability relationships of pure cannabinoids and their cocrystals under forced degradation conditions.
AI Summary
This study examined how pure cannabidiol (CBD), cannabinol (CBN), cannabigerol (CBG), and their cocrystals respond to heat, different pH conditions, oxidation, and light. The researchers focused on how molecular structure and the choice of a coformer—a second compound incorporated into a crystal—affect stability. The abstract reports no quantitative results, but it identifies clear differences among the tested formulations.
The findings suggest that coformer selection can improve thermal stability: 4,4'-bipyridine performed better than the pure cannabinoids under heat stress. Degradation was generally greater at intermediate pH values, while most samples showed little light-related instability. Radical-driven oxidation was more damaging than peroxide-driven oxidation, and the exposure of heteroatoms at the crystal surface also influenced stability. For cannabis product development, this work points to formulation and packaging strategies that may help preserve cannabinoid quality, although it does not directly assess effects in people or predict product shelf life.
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