How cannabis smoke damages lungs: what imaging reveals

Imaging Findings of Smoking-related Pulmonary Parenchymal Disease.

Radiographics : a review publication of the Radiological Society of North America, Inc • • Review • Moderately Relevant
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AI Summary

This research paper examines the imaging findings associated with smoking-related lung disease, with a notable focus on emerging health risks from e-cigarettes and marijuana inhalation. The study reviews how CT scanning can identify characteristic patterns in chronic obstructive pulmonary disease (COPD) and smoking-related interstitial lung diseases (SR-ILDs), which involve inflammatory and fibrotic processes in lung tissue. The authors emphasize that radiologists must distinguish between different types of smoking-related lung damage, as these conditions differ significantly in their progression, prognosis, and treatment approaches.

A critical finding for cannabis users is the inclusion of marijuana smoke inhalation as an emerging cause of pulmonary parenchymal disease. The paper highlights that smoking cannabis, like cigarette smoking, can produce characteristic imaging patterns on CT scans that radiologists need to recognize. The authors note that while many smoking-related conditions have distinctive features, significant overlap exists between different patterns, and patients may simultaneously have multiple conditions, complicating diagnosis. This has important implications for understanding the long-term respiratory consequences of cannabis smoking.

The research underscores that diagnostic accuracy depends on recognizing specific imaging manifestations associated with different inhalation exposures, including marijuana use. By improving radiologist awareness of how cannabis smoke affects lung tissue, this comprehensive review supports better clinical outcomes for cannabis-using patients. The inclusion of marijuana alongside e-cigarettes as an emerging inhalation injury concern reflects growing recognition in the medical community that cannabis smoking carries respiratory risks similar to other forms of smoke inhalation.

📄 Original Abstract

Cigarette smoking is a major cause of parenchymal lung disease, with a wide range of imaging findings that radiologists must be able to recognize. These include chronic obstructive pulmonary disease (COPD) and a group of diffuse interstitial lung diseases (ILDs) collectively referred to as smoking-related ILDs (SR-ILDs), which encompass inflammatory and fibrotic processes induced by smoking. Although many of these conditions exhibit characteristic imaging features, significant overlap is common, and multiple entities may coexist in the same patient and add difficulty to the diagnostic process. The distinction between SR-ILDs and other ILDs is critical, as they differ in behavior, prognosis, and management. CT of the chest plays a pivotal role in allowing radiologists to identify characteristic features, distinguish overlapping patterns, and guide multidisciplinary evaluation. The authors provide a comprehensive review of smoking-related parenchymal lung diseases, focusing on clinical, histopathologic, and especially radiologic features. The authors also review emerging inhalation injuries associated with e-cigarette and marijuana use, which further expand the spectrum of imaging findings. Radiologist awareness of these imaging manifestations is essential for improving diagnostic accuracy and guiding appropriate management. ©RSNA, 2026 Supplemental material is available for this article.

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