446 studies

Endocannabinoid System Research

Studies on the endocannabinoid system: CB1 and CB2 receptors, anandamide, 2-AG and how cannabis compounds act on them.

Latest Endocannabinoid studies

Mouse study finds tea extract eased G-CSF-related pain, not mobilization

Pain Endocannabinoid

In a mouse PTSD-like model, β-caryophyllene’s effects depended on CB2

Endocannabinoid Anxiety

Fluid lipid patterns distinguish schizophrenia groups in machine learning…

Endocannabinoid Mental Health

Review maps periosteal receptor changes with age; therapies remain untested

Endocannabinoid

Review explores dual-action CB2 ligands for neurological disorders

Endocannabinoid Neuroprotection Inflammation

GLP-1 drugs reduced migraine-like sensitivity in mice, with sex-specific…

Pain Endocannabinoid

Mouse study links SGIP1 loss to stronger CB1 inhibition during inflammation

Endocannabinoid Pain

A lab-made degrader lowered CB1 levels and altered cancer-cell behavior

Endocannabinoid Cancer

Review links orexin and endocannabinoid signalling, but clinical value remains…

Endocannabinoid Pain Anxiety

Systematic review links NAE-like compounds to TLR4 inflammation pathways

Endocannabinoid Inflammation

CBD reduced plaque and inflammation markers in an Alzheimer’s mouse model

CBD Neuroprotection Inflammation

Cell studies find anti-inflammatory activity from dual CB2R–FAAH compounds

Endocannabinoid Inflammation Neuroprotection

In fasted mice, POMC-CB1R signaling links threat to feeding suppression

Endocannabinoid

Leech synapses show opposing 2-AG effects across the same concentration ranges

Endocannabinoid Pain

Review finds CBD pain trials inconclusive, with liver safety concerns

Review links declining endocannabinoid activity to brain ageing; human…

Endocannabinoid THC Neuroprotection

Adolescent study finds sex differences in endocannabinoids and puberty

Endocannabinoid Pain Mental Health

Review links chronic social stress to circuit and hormone remodeling

Endocannabinoid Mental Health

Review finds strongest microbiome–endocannabinoid links in gut inflammation

Endocannabinoid Inflammation

Enriched housing altered mice’s intestinal ECS response to LPS inflammation

Endocannabinoid Inflammation

Lab assays challenge compound 36’s reported MAGL-inhibiting potency

Endocannabinoid

Mouse and cell studies link CB2 activation with less stroke injury and…

Endocannabinoid Inflammation Neuroprotection

A case report links postoperative THC vaping to thumb replant failure

THC Endocannabinoid

Mouse models link macrophage CB1R to psoriasis-like inflammation

Endocannabinoid Inflammation

In Lafora disease mice, CBD and D2 activation restored striatal plasticity

CBD Epilepsy Endocannabinoid

Placental study links pregnancy cannabis exposure with signaling and…

THC Endocannabinoid

Cannabis co-use linked to lower cessation odds; CBD evidence remains preliminary

CBD Endocannabinoid Addiction

Astrocyte CB1 activation dampens combined signals in amygdala cells

Endocannabinoid

Review finds mixed evidence for endocannabinoid approaches to mood

Endocannabinoid Anxiety Mental Health

A review links 2-AG to obesity pathways but not proven treatments

Endocannabinoid Appetite Inflammation

Rat study links atherosclerosis stage to changing CB1 and CB2 activity

Endocannabinoid

Brain endocannabinoid signaling limited PTSD-like behaviors in a stress model

Endocannabinoid Anxiety Mental Health

In fragile X mice, CB1 blockade shifts synaptic RNA splicing toward normal

Endocannabinoid Mental Health

Visceral fat endocannabinoid production rose with diabetes, not obesity alone

Endocannabinoid

Review links cannabis to possible heart attack mechanisms, not proven risk

Endocannabinoid

Targeted CB2 drug delivery reduced mouse plaque deposits, with sex differences

Endocannabinoid Inflammation

A review links endocannabinoids to hypothalamic appetite and reward feeding

Appetite Endocannabinoid

In mice, cannabinoids increased threat responses and amygdala activity

Mental Health Neuroprotection Endocannabinoid

Lab tests support Pep-5 as a possible CB2 allosteric modulator

Endocannabinoid

Review finds promise in acidic cannabinoids, but human benefits remain unproven

THC CBD Epilepsy

Rat study links β-caryophyllene’s antifibrotic effects to CB2 signaling

Inflammation Endocannabinoid

Adolescent lipid levels covary with brain structure, but causation is unknown

Endocannabinoid

In reserpine-treated mice, both receptor blockers raised force, but only CB1…

Endocannabinoid

In male mice, CBD lowered some cytokines and reshaped liver gene activity

CBD Inflammation Endocannabinoid

Higher baseline anandamide linked to fewer general symptoms at follow-up

Endocannabinoid Mental Health

Review surveys headache targets beyond CGRP, including early endocannabinoid…

Endocannabinoid Pain Neuroprotection

Review maps cannabis immunity research and highlights gaps before field use

Endocannabinoid

Mouse incision study links peripheral CB1 activation to reduced pain via ASIC3

Pain Endocannabinoid

See all 446 Endocannabinoid studies →

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Other research topics

Every study on the site, grouped by what it measured.

Mental Health 742 Addiction 654 THC 435 CBD 354 Neuroprotection 287 Pain 272 Inflammation 270 Anxiety 114 Cancer 96 Sleep 85 Epilepsy 67 Terpenes 62 Appetite 37 Nausea 37 Policy 2

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